Friday, July 26, 2013

Bristol cuts forecast, new blood clot drug struggles

By Ransdell Pierson

(Reuters) - U.S. drugmaker Bristol-Myers Squibb Co cut its full-year revenue and earnings forecasts and posted disappointing sales of its new drug to prevent blood clots and its once-weekly Bydureon diabetes drug.

Eliquis, the blood clot drug, eked out second-quarter global sales of $12 million, the company said on Thursday, following highly disappointing U.S. sales of $17 million in the first quarter. Investors have counted on the drug to be one of the company's biggest engines of sales growth.

"Today's emphasis will likely be on disappointing Eliquis and Bydureon sales," Leerink Swann analyst Seamus Fernandez said, adding they suggested "challenges" for Bristol-Myers and partners that sell the drugs to primary care doctors.

Bydureon, acquired through Bristol's recent purchase of Amylin Pharmaceuticals, posted quarterly sales of $66 million, almost $50 million below Fernandez's forecast. He said the injectable drug is facing tough competition from Novo Nordisk's Victoza, and warned new rivals will emerge in the next few years.

Eliquis, which Bristol-Myers sells in partnership with Pfizer Inc, was approved by U.S. regulators in late December to prevent strokes among patients with atrial fibrillation, an irregular heartbeat most common among the elderly.

Studies have suggested Eliquis is the best among a crop of new oral medicines meant to replace warfarin, the standard oral stroke-prevention treatment for a half century that has dietary restrictions and requires frequent blood tests to avert potentially dangerous bleeding.

"The Eliquis numbers will trigger quite a few downgrades of Bristol-Myers" by Wall Street analysts, Atlantic Equities analyst Richard Purkiss predicted.

Purkiss said Bristol-Myers and Pfizer apparently failed to recognize how much investment was needed to promote Eliquis. It competes with Xarelto, from Bayer AG and Johnson & Johnson and approved in November 2011.

It also competes with Boehringer Ingelheim's Pradaxa, a new anti-clot pill that works through a different mechanism. Pradaxa posted sales of $1.43 billion in 2012, its second year on the market.

LOW TAX RATE HELPS

Bristol-Myers said it earned $536 million, or 32 cents per share, in the second quarter. That compared with $645 million, or 38 cents per share, in the year-earlier quarter.

Excluding special items, including combined charges of $274 million for restructuring and pension settlements, Bristol-Myers earned 44 cents per share, matching analysts' estimates in a poll by Thomson Reuters I/B/E/S.

Fernandez said a lower-than-expected tax rate was the primary reason the "low quality" second-quarter results met Wall Street expectations.

Global revenue fell 9 percent to $4.05 billion, in line with Wall Street targets. The decline was fueled by generic competition for its Plavix blood clot preventer and Avapro blood pressure treatment.

The company trimmed its full-year 2013 profit forecast to between $1.70 and $1.78 per share from its earlier view of $1.78 to $1.88.

Bristol-Myers also lowered its full-year sales forecast to between $16 billion and $16.5 billion from its prior view of $16.2 to $17.2 billion.

The stock rose 0.7 percent to $44.92 on mid-morning trade.

(Reporting by Ransdell Pierson; Editing by Michele Gershberg, Maureen Bavdek and Jeffrey Benkoe)

Source: http://news.yahoo.com/bristol-cuts-forecast-blood-clot-drug-struggles-143924288.html

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Reach Your Home Business Dreams With These Smart Tips ...

Running a home business has many advantages, but there are some disadvantages to it as well. This is particularly true if you have no idea what you are doing. You can avoid these common mistakes with some research. This article contains some useful information that will help you to have a thriving business.

You can deduct the cost of your Internet connection when you work from home. Keep in mind that the percentage that you deduct from your bottom line can only be what is used exclusively for your business and not for other uses.

When you start a home business, there are many responsibilities to consider. One way to help ensure success is to find your own niche. Pick an audience and a product you are already familiar with if possible. You want to research as much as possible and expand instead of putting everything into one narrow-minded basket. Network with other home business owners to get an better idea of which sectors are the best.

Online forums can offer you a wealth of home business information. Search the internet and you will find a lot of great forums that you can become a part of. There are also many online blogs that you will find helpful.

You can decrease family interruptions while you are working at home. Interruptions can corrode your productivity, so tell everyone when you will start working ? and when you will be done. It is important that they understand that privacy is needed and will allow you to spend time with them just as soon as you complete your work. Be certain your kids are being watched and stay accessible in case of emergencies.

When you have a product or service to sell, always check out what your competition is charging. Price the item or service as offered by your competitors, and aim your price just slightly lower. Instead of focusing on the competition?s negative qualities, put the focus on your product?s positive qualities.

Your business? name must have personal meaning. Buy a domain name for your business, even if you haven?t planned the site out. Most domains are fairly inexpensive, and it is a good idea to establish one as soon as possible. When you are still trying to decide whether you need a full website, post a page that has all of your business information on it.

Other people who work from home can offer support via an online forum. There are many sites and forums to choose from that offer a variety of support to a home business owner. The understand from others in similar situations is invaluable. There will be other home business owners that can give you advice and tips.

Save money by keeping good records about any expenditures you make for your business. Internet service and car mileage related to your business are a couple examples of business expenses. When you run a business, a lot of your expenses are tax deductible. These expenses add up fast; there?s no point in giving the government money that you can keep.

When setting up your home business, be sure to have a properly written business plan. No matter the size of your business, make sure you plan out your goals and how you will get there. As your business expands, the business plan you write will help keep things growing in the right direction.

Before you start your business, it is important to figure out which audience you want to target. Though you may be well versed in your services and products, knowing what your market is and where their needs lie, will help you create the right sales and marketing plan that will bring them to your site. Design your website according to how the target audience prefers to interact with their online choices.

By taking heed of this advice, you can focus on areas of your business that are successful, rather than finding the pitfalls that others before you have already investigated. This will allow you to spend more time succeeding instead of struggling with your home business.

At Web Design Glasgow, we help businesses get more visitors and convert visitors into customers using various online marketing techniques such as Search Engine Optimisation, Email Marketing and Social Media Marketing.

We are a member of Synergy Business Services Club. If you would like to receive articles important for your business, please subscribe to SBS Newsletter using the following form:

Source: http://www.synergybusinessservices.co.uk/blog/reach-your-home-business-dreams-with-these-smart-tips/

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Strata-X Updates Burkett 5-34HOR Well, Reports Oil Shows, Vail Oil Project

By Marketwire .

Article Rating:

July 24, 2013 07:30 PM EDT

Reads:

213

DENVER, COLORADO and BRISBANE, QUEENSLAND and VANCOUVER, BRITISH COLUMBIA -- (Marketwired) -- 07/24/13 -- The directors and management of Strata-X Energy Ltd. ("Strata-X" or the "Company") (TSX VENTURE:SXE)(ASX:SXA) are pleased to announce that the Company has reached total depth (4,730 ft) on the vertical drilling of the Burkett 5-34HOR well for the Vail Oil Project. In drilling the vertical portion of the well, oil and gas shows were encountered in the targeted Devonian Lingle formation and a drill stem test of the target recovered gas and oil cut mud. Coring of the target zone was completed with the Company recovering 59 feet of core. The core is presently being processed at the Weatherford core facilities in Colorado for analysis. Preliminary results indicate approximately 10 feet of oil saturation in the Lingle Formation which is in line with Company expectations. Well logs have been successfully run and operations to set the kick off plug are underway before proceeding to the horizontal portion of the well. The Company owns a 100% working interest in the well and in 48,000 net acres in the project overall.

The Burkett 5-34HOR well is being drilled in Clay County, Illinois, west of the town of Xenia, Illinois. As previously announced (Press Release dated April 7, 2013), the Company executed a Drilling Contract with Les Wilson Inc. for the Burkett 5-34HOR well which is expected to test the Devonian Lingle formation, a dolomitic reservoir which lies directly below the hydrocarbon rich New Albany Shale.

As previously announced (Press Release dated July 17, 2013) the Company has released an Investor Presentation on the Vail Oil Project which can be found www.strata-x.com.

About Strata-X

Strata-X is a Denver, Colorado (USA) based company and is engaged in the business of oil and gas exploration and development with a variety of exploration opportunities in North Dakota, California, Colorado, Texas, Illinois and Western Australia and production and development opportunities in California. Strata-X has 123,752,453 common shares outstanding and trades under the symbol "SXE" on the TSX-V and "SXA" on the ASX.

This announcement was made in Canada for the TSX.V and in Australia for the ASX.

Public documents for Strata-X Energy Ltd. can be found at SEDAR (Canada) (www.sedar.com) and ASX.com.au (Australia).

By definition of the COGE Handbook - "Undiscovered resources are those quantities of oil and gas estimated on a given date to be contained in accumulations yet to be discovered." The Handbook further states - Caution (per NI 51-101/5.9(2)(v)(B)) - "There is no certainty that any portion of the resources will be discovered. If discovered, there is no certainty that it will be commercially viable to produce any portion of the resources." In addition, per NI 51-101/5.6 "the estimated values disclosed do not represent fair market value."

CAUTIONARY STATEMENTS

This news release contains forward-looking statements, which relate to future events or future performance and reflect management's current expectations and assumptions. The use of any of the words "anticipate", "continue", "estimate", "expect", 'may", "will", "project", "should", 'believe", and similar expressions is intended to identify forward-looking statements. Such forward-looking statements reflect management's current beliefs and are based on assumptions made by and information currently available to the Company. Readers are cautioned that these forward-looking statements are neither promises nor guarantees, and are subject to risks and uncertainties that may cause future results to differ materially from those expected and the forward-looking statements included in this news release should not be unduly relied upon. See "Risks and Uncertainties" in the Company's Filing Statement dated August 30, 2011 available on SEDAR at www.sedar.com. These forward-looking statements are made as of the date hereof and the Company does not assume any obligation to update or revise them to reflect new events or circumstances save as required under applicable securities legislation. This news release does not constitute an offer to sell securities and the Company is not soliciting an offer to buy securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of such jurisdiction.

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Source: http://www.sys-con.com/node/2746657

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Thursday, July 25, 2013

Color patterns in fish larvae may reveal relationships among species

[unable to retrieve full-text content]Similarities in how different organisms look can indicate a close evolutionary relationship. Conversely, great differences in appearance can suggest a very distant relationship, as in many adult marine fish species. For the first time, however, a scientist has found that color patterns of different fish species in the larval stage can be very similar, revealing a closer evolutionary relationship than their adult forms would suggest.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/LboyNKb7dLw/130724200609.htm

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iMore show live! Apple Q3 2013 earnings post-mortem!

Join me and our Mobile Nations financial guru, Chris Umiastowski as we go over the highs and lows of Apple's just-released Q3 2013 financial results and the follow up conference call.

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/DtTgKvmSYjk/story01.htm

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Bynes hospitalized after allegedly starting fire

Amanda Bynes, accompanied by attorney Gerald Shargel, arrives for a court appearance in New York, Tuesday, July 9, 2013. The 27-year-old actress is charged with reckless endangerment and attempted tampering with physical evidence. Bynes was arrested in May after building officials called police to complain she was smoking pot in the lobby. Officers went to her apartment where they say they saw a bong sitting on the kitchen counter. Prosecutors say she tossed the bong out the window in front of the officers. (AP Photo/Bethan McKernan)

Amanda Bynes, accompanied by attorney Gerald Shargel, arrives for a court appearance in New York, Tuesday, July 9, 2013. The 27-year-old actress is charged with reckless endangerment and attempted tampering with physical evidence. Bynes was arrested in May after building officials called police to complain she was smoking pot in the lobby. Officers went to her apartment where they say they saw a bong sitting on the kitchen counter. Prosecutors say she tossed the bong out the window in front of the officers. (AP Photo/Bethan McKernan)

(AP) ? Actress Amanda Bynes was hospitalized for a mental health evaluation after deputies said she started a small fire in the driveway of a home in Southern California.

Deputies responding to a 911 call Monday night found Bynes, 27, standing next to the flames in the city of Thousand Oaks, according to Ventura County sheriff's Capt. Don Aguilar.

The deputies determined she met the criteria for a mental health hold and took her into custody. She can be held for up to 72 hours of observation.

No charges were filed, Aguilar said.

Richard Hutton and David Feldman, who are listed as Bynes' attorneys in industry databases, refused to comment Tuesday.

The former Nickelodeon actress has had several run-ins with the law in California. In December, the "Hairspray" star resolved a misdemeanor hit-and-run case after entering into a civil settlement with other drivers. She was charged last fall with driving on a suspended license after it was temporarily taken away from her following two hit-and-run cases where she was accused of leaving the scene without providing proper information. She has also pleaded not guilty to drunken driving in a separate case.

Earlier this month Bynes appeared in a New York court on allegations that she chucked a marijuana bong out the window of her 36th-floor Manhattan apartment.

She also has taken to social media to criticize a host of celebrities recently.

In the late 1990s and early 2000s Bynes was one of the hottest actors on children's TV.

Beginning in 2000, she won four consecutive Kids Choice Awards for best television actress, the first for her role in the ensemble kids comedy-variety show "All That" and the others for her starring vehicle "The Amanda Show." She also received Kids Choice Awards for best movie actress awards in 2003 and 2004 for the films "Big Fat Liar" and "What A Girl Wants."

Bynes, who grew up in Thousand Oaks, also starred in the popular television series "What I Like About You," which aired from 2002 to 2006, and several TV movies before her career began to decline.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-07-23-US-People-Amanda-Bynes/id-653854d984374a70aaa1e6a3079d26c8

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